Resistance to the artemisinin derivatives, our most effective antimalarial drugs, has not manifest as a classical resistance phenotype in which parasites can tolerate higher drug concentrations. Instead, resistant parasites have an altered maturation. We hypothesize that the short half-life of artemisinin concentrations is an unanticipated driver of this novel resistance phenotype.

中文翻译：

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青蒿素耐药性和短效抗疟药的独特选择压力。

对青蒿素衍生物（我们最有效的抗疟药）的抗药性尚未表现出经典的抗药性表型，在这种表型中，寄生虫可以耐受更高的药物浓度。相反，抗药性寄生虫的成熟度会发生变化。我们假设青蒿素浓度短的半衰期是这种新型耐药表型的意外驱动因素。