Comprehensive two-dimensional gas chromatography (C2DGC) offers excellent separation efficiency that serves advanced analysis of volatiles and semi-volatiles in multicomponent and multiple chemical class samples. This review presents an overview of concepts and experimental approaches to continuous flow C2DGC starting from classical single injection C2DGC (conventional GC×GC) to using repeat injections with a longer second column. A strategy of multiple heart-cut multidimensional GC (CH/C MDGC) to construct a variant that is also comprehensive in concept is reviewed, along with various methods – a continuum – between these extremes. Recent selectivity-optimised systems in GC×GC, including new stationary phases or other multiple column arrangements and their applications are also highlighted. The review presents a fundamental background to guide column selection for specific applications in conjunction with experimental design, and future trends.

全面的二维气相色谱（C2DGC）具有出色的分离效率，可对多组分和多种化学类别样品中的挥发物和半挥发物进行高级分析。这篇综述对连续流C2DGC的概念和实验方法进行了概述，从经典的单次进样C2DGC（常规GC×GC）到使用更长的第二根色谱柱进行重复进样。审查了多重心切多维GC（CH / C MDGC）构造在概念上也很全面的变体的策略，以及这些极端之间的各种方法（一个连续统）。还重点介绍了最近在GC×GC中选择性优化的系统，包括新的固定相或其他多色谱柱布置及其应用。