Germacranolides from Elephantopus scaber L. and their cytotoxic activities,Phytochemistry

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Germacranolides from Elephantopus scaber L. and their cytotoxic activities
Phytochemistry ( IF 3.2 ) Pub Date : 2020-10-01 , DOI: 10.1016/j.phytochem.2020.112479
Ming Bai ₁ , Jing-Jie Chen ₁ , Wei Xu ₁ , Shu-Hui Dong ₁ , Qing-Bo Liu ₁ , Guo-Dong Yao ₁ , Bin Lin ₂ , Xiao-Xiao Huang ₁ , Shao-Jiang Song ₁

Affiliation

Seven undescribed germacranolides, named as scabertopinolide A-G were obtained from whole herbs of Elephantopus scaber L. The determination of their structures was conducted via comprehensive spectroscopic analyses combined with experimental electronic circular dichroism (ECD) spectroscopic data and quantum mechanical ECD calculations. The absolute configuration of scabertopinolide A was determined by X-ray crystallography data analysis. The cytotoxicity of all compounds was evaluated against three human cancer cell lines HepG2, Hep3B (human hepatocellular carcinoma cell lines), and MCF-7 (human breast adenocarcinoma cell line). Scabertopinolide G exhibited the most significant cytotoxic activities against the three cancer cell lines with IC50 values between 7.0 and 10.3 μM. Furthermore, flow cytometry analysis has suggested that scabertopinolide G may cause death of cancer cells through apoptosis induction.

中文翻译：

来自 Elephantopus scaber L. 的 Germacranlides 及其细胞毒活性

从 Elephantopus scaber L 的全草中获得了七种未描述的germacranolide，命名为scabertopinolide AG。通过综合光谱分析结合实验电子圆二色性(ECD) 光谱数据和量子力学ECD 计算来确定其结构。scabertopinolide A 的绝对构型通过 X 射线晶体学数据分析确定。针对三种人类癌细胞系 HepG2、Hep3B（人类肝细胞癌细胞系）和 MCF-7（人类乳腺癌细胞系）评估了所有化合物的细胞毒性。Scabertopinolide G 对三种癌细胞系表现出最显着的细胞毒活性，IC50 值介于 7.0 和 10.3 μM 之间。此外，

更新日期：2020-10-01

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