The negative symptoms of schizophrenia are linked to poorer functional outcomes and decreases in quality of life, and are often the first to develop in individuals who are at clinical high risk (CHR) for psychosis. However, the accompanying neurobiological changes are poorly understood. Therefore, we conducted a systematic review of the studies that have examined the brain metrics associated with negative symptoms in those at CHR.

Electronic databases were searched from inception to August 2019. Studies were selected if they mentioned negative symptoms in youth at CHR for psychosis, and brain imaging. Of 261 citations, 43 studies with 2144 CHR participants met inclusion criteria. Too few studies were focused on the same brain regions using similar neuroimaging methods to perform a meta-analysis, however, the results of this systematic review suggest a relationship between negative symptom increases and decreases in grey matter. The paucity of studies linking changes in brain structure and function with negative symptoms in those at CHR suggests that future work should focus on examining these relationships.

精神分裂症的阴性症状与较差的功能结果和生活质量的下降有关，并且通常是在患有精神病临床高危 (CHR) 的个体中首先出现的症状。然而，伴随的神经生物学变化知之甚少。因此，我们对已检查与 CHR 患者的阴性症状相关的大脑指标的研究进行了系统评价。

从开始到 2019 年 8 月对电子数据库进行了搜索。如果研究提到 CHR 青年精神病和脑成像的阴性症状，则选择这些研究。在 261 篇引文中，有 2144 名 CHR 参与者的 43 项研究符合纳入标准。很少有研究关注相同的大脑区域，使用类似的神经影像学方法进行荟萃分析，然而，这项系统评价的结果表明，负面症状增加和灰质减少之间存在关系。很少有研究将大脑结构和功能的变化与 CHR 的阴性症状联系起来，这表明未来的工作应该集中在检查这些关系上。