While nitric oxide (NO) can remedy vasoconstriction, inhalation of NO may cause systematic toxicity. We report a goldsome, which comprises a hollowed poly(lactic-co-glycolic acid) (PLGA) polymersome with S-nitrosoglutathione (GSNO, a NO donor) molecules and gold nanoparticles (Au NPs) incorporated in its hydrophilic core and hydrophobic membrane, respectively. Photothermal heating caused breakdown of polymersomes and enabled NO generation through reaction between GSNO and Au NPs. Photo-illumination at the zebrafish head led to local NO generation and selective cerebral vasodilation while it had little effects in regions away from the illumination site, and effectively mitigated hypoxia induced cerebral vasoconstriction. We demonstrate a translational potential by showing photo-stimulated NO generation with a clinical intravascular optical catheter. In conclusion, the goldsome, which enables light stimulated local NO generation and can be delivered with clinical intravascular optical catheters, should extend applications of NO therapies while surmounting limitations associated with systemic administration.

虽然一氧化氮 (NO) 可以治疗血管收缩，但吸入 NO 可能会导致全身毒性。我们报告了一个金色的，它包含一个中空的聚（乳酸-乙醇酸共聚物）（PLGA）聚合物体，其中 S-亚硝基谷胱甘肽（GSNO，NO 供体）分子和金纳米颗粒（Au NPs）分别结合在其亲水核和疏水膜中。光热加热导致聚合物囊泡分解，并通过 GSNO 和 Au NPs 之间的反应生成 NO。斑马鱼头部光照射导致局部NO生成和选择性脑血管舒张，而在远离照射部位的区域几乎没有影响，并有效减轻缺氧引起的脑血管收缩。我们通过使用临床血管内光导管显示光刺激 NO 生成来证明其转化潜力。总之，金毛使光刺激局部 NO 生成并可以通过临床血管内光导管递送，应该扩展 NO 疗法的应用，同时克服与全身给药相关的限制。