Asthma among hospitalized patients with COVID-19 and related outcomes.,Journal of Allergy and Clinical Immunology

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Asthma among hospitalized patients with COVID-19 and related outcomes.
Journal of Allergy and Clinical Immunology ( IF 11.4 ) Pub Date : 2020-08-06 , DOI: 10.1016/j.jaci.2020.07.026
Stephanie Lovinsky-Desir ₁ , Deepti R Deshpande ₂ , Aliva De ₁ , Laurie Murray ₃ , Jeanette A Stingone ₄ , Angela Chan ₂ , Neha Patel ₁ , Nooralam Rai ₁ , Emily DiMango ₅ , Joshua Milner ₂ , Meyer Kattan ₁

Affiliation

Background

Several underlying conditions have been associated with severe acute respiratory syndrome coronavirus 2 illness, but it remains unclear whether underlying asthma is associated with worse coronavirus disease 2019 (COVID-19) outcomes.

Objective

Given the high prevalence of asthma in the New York City area, our objective was to determine whether underlying asthma was associated with poor outcomes among hospitalized patients with severe COVID-19 compared with patients without asthma.

Methods

Electronic heath records were reviewed for 1298 sequential patients 65 years or younger without chronic obstructive pulmonary disease who were admitted to our hospital system with a confirmed positive severe acute respiratory syndrome coronavirus 2 test result.

Results

The overall prevalence of asthma among all hospitalized patients with COVID-19 was 12.6%, yet a higher prevalence (23.6%) was observed in the subset of 55 patients younger than 21 years. There was no significant difference in hospital length of stay, need for intubation, length of intubation, tracheostomy tube placement, hospital readmission, or mortality between patients with and without asthma. Observations between patients with and without asthma were similar when stratified by obesity, other comorbid conditions (ie, hypertension, hyperlipidemia, and diabetes), use of controller asthma medication, and absolute eosinophil count.

Conclusions

Among hospitalized patients 65 years or younger with severe COVID-19, asthma diagnosis was not associated with worse outcomes, regardless of age, obesity, or other high-risk comorbidities. Future population-based studies are needed to investigate the risk of developing COVID-19 among patients with asthma once universal testing becomes readily available.

中文翻译：

COVID-19 住院患者的哮喘及相关结果。

背景

一些潜在的疾病与严重急性呼吸综合征冠状病毒 2 疾病有关，但目前尚不清楚潜在的哮喘是否与 2019 年冠状病毒病 (COVID-19) 的更严重结果相关。

客观的

鉴于纽约市地区哮喘发病率较高，我们的目的是确定与非哮喘患者相比，患有重症 COVID-19 的住院患者中潜在的哮喘是否与不良预后相关。

方法

对 1298 名 65 岁或以下、无慢性阻塞性肺疾病的连续患者的电子健康记录进行了审查，这些患者入住我们医院系统，并确认严重急性呼吸综合征冠状病毒 2 检测结果呈阳性。

结果

所有住院的 COVID-19 患者中哮喘的总体患病率为 12.6%，但在 21 岁以下的 55 名患者中观察到更高的患病率 (23.6%)。患有和不患有哮喘的患者在住院时间、插管需求、插管长度、气管切开插管放置、再入院或死亡率方面没有显着差异。当按肥胖、其他合并症（即高血压、高脂血症和糖尿病）、控制哮喘药物的使用和绝对嗜酸性粒细胞计数进行分层时，患有和不患有哮喘的患者之间的观察结果相似。