Photothermal therapy (PTT) was considered as one of the most promising cancer therapies to overcome the severe side effects caused by chemotherapy. Hence, four thiophene analogs were developed to construct novel organic photothermal agents (PTAs) for many biomedical applications in cancer biosensing and photothermal therapies. The efficacy of four compounds was demonstrated by studies of photothermal properties as well as photothermal therapeutic effects. Besides, tumor ablation experiments indicated that HTN2 can effectively suppress tumors in vivo and in vitro as a novel PTA. Hence, PTAs that we designed and synthesized with their advantage of good biocompatibility and facile structural design could be candidates for PTT.

光热疗法（PTT）被认为是克服化疗引起的严重副作用的最有前途的癌症疗法之一。因此，开发了四种噻吩类似物来构建新型有机光热剂（PTA），用于癌症生物传感和光热疗法中的许多生物医学应用。通过光热特性和光热治疗效果的研究证明了四种化合物的功效。此外，肿瘤消融实验表明HTN2作为一种新型PTA可以在体内和体外有效抑制肿瘤。因此，我们设计和合成的 PTA 具有良好的生物相容性和易于结构设计的优点，可以作为 PTT 的候选者。