Molecular diagnostic technologies for COVID-19: Limitations and challenges.,Journal of Advanced Research

当前位置： X-MOL 学术 › J. Adv. Res. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Molecular diagnostic technologies for COVID-19: Limitations and challenges.
Journal of Advanced Research ( IF 11.4 ) Pub Date : 2020-08-06 , DOI: 10.1016/j.jare.2020.08.002
Adeel Afzal ₁

Affiliation

Background

To curb the spread of the COVID-19 (coronavirus disease 2019) pandemic, the world needs diagnostic systems capable of rapid detection and quantification of the novel coronavirus (SARS-CoV-2). Many biomedical companies are rising to the challenge and developing COVID-19 diagnostics. In the last few months, some of these diagnostics have become commercially available for healthcare workers and clinical laboratories. However, the diagnostic technologies have specific limitations and reported several false-positive and false-negative cases, especially during the early stages of infection.

Aim

This article aims to review recent developments in the field of COVID-19 diagnostics based on molecular technologies and analyze their clinical performance data.

Key Concepts

The literature survey and performance-based analysis of the commercial and pre-commercial molecular diagnostics address several questions and issues related to the limitations of current technologies and highlight future research and development challenges to enable timely, rapid, low-cost, and accurate diagnosis of emerging infectious diseases.

中文翻译：

COVID-19 分子诊断技术：局限性和挑战。

背景

为了遏制 COVID-19（2019 冠状病毒病）大流行的传播，世界需要能够快速检测和定量新型冠状病毒（SARS-CoV-2）的诊断系统。许多生物医学公司正在迎接挑战并开发 COVID-19 诊断方法。在过去的几个月中，其中一些诊断方法已经可供医疗保健工作者和临床实验室使用。然而，诊断技术具有特定的局限性，并报告了一些假阳性和假阴性病例，特别是在感染的早期阶段。