The interaction of tolerogenic CD103⁺ dendritic cells (DCs) with regulatory T (Tregs) cells modulates immune responses by inducing immune tolerance. Hence, we determined the proportion of these cells in the peripheral blood mononuclear cells (PBMC) of asthmatic patients. We observed lower trends of CD11b^-CD103⁺ DCs and CD86 within CD11b^-CD103⁺ DCs, while increased levels of Foxp3 expressing CD25^+/-TNFR2⁺ cells in asthmatics. There was a positive correlation in the expression of Foxp3 within CD3⁺CD4⁺CD25⁺TNFR2⁺ Tregs and CD11b^-CD103⁺ as well as the expression of CD86 within HLA-DR⁺CD11c⁺CD11b^-CD103⁺ DCs. In conclusion, we suggest that the increased levels of Tregs in blood could continuously suppress the T helper 2 (Th2) cells activation in the circulation which is also supported by the increase of anti-inflammatory cytokines IL-10 and TNF. Overall, functional immunoregulation of the regulatory cells, particularly Tregs, exhibit immune suppression and induce immune tolerance linked with the immune activation by the antigen presenting cells (APC).

致耐受性CD103 ⁺树突状细胞（DC）与调节性T（Tregs）细胞的相互作用通过诱导免疫耐受来调节免疫反应。因此，我们确定了这些细胞在哮喘患者外周血单个核细胞（PBMC）中的比例。我们观察到的CD11b降低的趋势^- CD103 ⁺细胞CD11b内DC和CD86 ^- CD103 ⁺的DC，而增加Foxp3的水平表达CD25 ^+/- TNFR2 ⁺哮喘细胞。CD3 ⁺ CD4 ⁺ CD25 ⁺ TNFR2 ⁺ Tregs和CD11b-中Foxp3的表达呈正相关^-CD103 ⁺以及HLA-DR ⁺ CD11c ⁺ CD11b ^- CD103 ⁺ DC中CD86的表达。总之，我们认为血液中Treg的水平升高可以持续抑制循环中的T辅助2（Th2）细胞活化，这也受到抗炎细胞因子IL-10和TNF含量增加的支持。总体而言，调节细胞，特别是Treg的功能性免疫调节表现出免疫抑制作用，并诱导与抗原呈递细胞（APC）的免疫激活相关的免疫耐受。