The present study investigated the accumulation and depuration effects of hexavalent chromium (Cr⁶⁺) in ten tissues (gills, intestines, liver, kidney, blood, heart, bladder, spleen, skin and muscle) of the bighead carp (Aristichthys nobilis). Fish were exposed to graded levels of waterborne Cr⁶⁺ (0.01, 0.1, 1 and 5 mg/L) for 4, 7 and 14 days, and subsequently transferred to Cr⁶⁺-free water for 14 days. After 14-day exposure, a dose-dependent increase of Cr⁶⁺ has been observed in most tissues. While after 14-day depuration, Cr⁶⁺ contents were significantly decreased in various tissues except in kidney and spleen where Cr⁶⁺ contents significantly increased at the group of 5 mg/L. Considering that Cr⁶⁺ highly accumulated in gills, intestines, liver and kidney, the oxidative damage of Cr⁶⁺ on the four tissues were further investigated and found that the antioxidant response to Cr⁶⁺ were organ-specific. The results in this study indicated that a 14-day period is effective for accumulation and depuration of Cr⁶⁺ in bighead carp and there was no health risk of fish muscle consumption. Additionally, the delayed efflux of Cr⁶⁺ in the fish kidney and spleen indicates that high importance should be attached to them when evaluating the toxic effects and risk assessments of Cr⁶⁺.

本研究调查了六价铬（Cr的积累和净化效果⁶⁺十个组织）鳙鱼（鳃，肠，肝，肾，血液，心脏，膀胱，脾，皮肤和肌肉）（鳙）。将鱼暴露在分级水平的水性Cr ⁶⁺（0.01、0.1、1和5 mg / L）中4、7和14天，然后转移到^不含Cr ^6+的水中14天。暴露14天后，在大多数组织中观察到了Cr ⁶⁺的剂量依赖性增加。净化14天后，除肾脏和脾脏中Cr ⁶⁺含量外，其他组织中的Cr ⁶⁺含量均明显降低。在5 mg / L的组中含量显着增加。考虑到Cr ⁶⁺在g，肠，肝和肾中高度积累，进一步研究了Cr ⁶⁺在四个组织上的氧化损伤，发现其对Cr ⁶⁺的抗氧化反应是器官特异性的。这项研究的结果表明，14天的时间对is鱼中Cr ^6+的积累和净化是有效的，并且没有食用鱼肌肉的健康风险。此外，Cr ⁶⁺在鱼肾和脾脏中的延迟流出表明，在评估Cr ⁶⁺的毒性作用和风险评估时，应高度重视它们。