Endometriosis is a condition in which tissue similar to the womb lining begins to grow in other sites, such as the ovaries or fallopian tubes. Endometriosis can cause pelvic pain, adhesion formation, and infertility. Here, we investigated the relationship between deterioration of endometriosis and inflammation of intraperitoneal adipose tissue in mice. We created a mouse model of endometriosis, then subjected these mice to stress loading. In the experimental mice, we measured protein expression levels of prostaglandin-E2, monocyte chemoattractant protein-1, and tumor necrosis factor-α using ELISA kits. We used quantitative real-time polymerase chain reaction to measure mRNA expression levels of inflammation-related enzymes and cytokines in lesions and adipose tissues. This study sugest that endometriotic lesions may progress in the presence of psychological stress in the presence of endometriosis. In addition, inflammation of the adipose tissue around the uterus may be involved in the development of endometriosis. However, this needs further consideration. Reducing or avoiding stress as much as possible may prevent the progression of endometriosis.

中文翻译：

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精神压力促进小鼠子宫内膜异位病变的增殖

子宫内膜异位症是一种类似于子宫内膜的组织开始在其他部位（例如卵巢或输卵管）生长的病症。子宫内膜异位症可导致盆腔疼痛、粘连形成和不孕。在这里，我们研究了小鼠子宫内膜异位症恶化与腹膜内脂肪组织炎症之间的关系。我们创建了子宫内膜异位症的小鼠模型，然后让这些小鼠承受压力负荷。在实验小鼠中，我们使用 ELISA 试剂盒测量了前列腺素-E2、单核细胞趋化蛋白-1 和肿瘤坏死因子-α 的蛋白质表达水平。我们使用定量实时聚合酶链反应来测量病变和脂肪组织中炎症相关酶和细胞因子的 mRNA 表达水平。该研究表明，子宫内膜异位症的存在可能会在心理压力的存在下进展。此外，子宫周围脂肪组织的炎症可能与子宫内膜异位症的发展有关。但是，这需要进一步考虑。尽可能减少或避免压力可以防止子宫内膜异位症的进展。