Senescence is a critical factor in several diseases, yet senolytic therapies targeting senescent cells remain hindered by lack of specificity. In the June issue of Nature, Amor et al. (2020) develop chimeric antigen receptor (CAR)-T cells targeting uPAR, a novel senescent-cell marker, to treat liver adenocarcinoma and liver fibrosis.

中文翻译：

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一种靶向衰老细胞的新方法：CAR-T细胞增强衰老特异性。

衰老是几种疾病的关键因素，但是针对特异性衰老细胞的柔脂疗法仍然受到阻碍。在《自然》杂志的六月刊中，Amor等人。（2020）开发针对uPAR（一种新型的衰老细胞标记）的嵌合抗原受体（CAR）-T细胞，以治疗肝腺癌和肝纤维化。