As humans age, hematopoietic stem cells (HSCs) occasionally acquire mutations in genes including DNMT3A that enable them to outcompete other HSCs and increase leukemia risk. In this issue of Cell Stem Cell, Tovy et al. (2020) report a previously uncharacterized mechanism by which DNMT3A loss confers increased fitness to HSCs by analyzing a rare experiment of nature.

中文翻译：

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播种克隆性造血种子。

随着人类年龄的增长，造血干细胞（HSC）偶尔会获得包括DNMT3A在内的基因突变，从而使其能够与其他HSC竞争，并增加患白血病的风险。在本期《细胞干细胞》中，Tovy等人。（2020）报道了一个以前未知的机制，通过分析罕见的自然实验，DNMT3A的丧失赋予了它对HSC适应性的提高。