Serotonin production by enterochromaffin cells (ECs) is microbiota-dependent, but the mechanism of this is unknown. In this issue of Cell, Sugisawa et al. demonstrate that Piezo1 in ECs senses single-strand RNA (ssRNA) from intestinal microbiota to promote serotonin production. Deletion of Piezo1 in intestinal epithelium promotes bone formation, decreases peristalsis, and protects from colitis because of decreased serotonin.

中文翻译：

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微生物 RNA 压力 Piezo1 做出反应。

肠嗜铬细胞 (EC) 产生的血清素依赖于微生物群，但其机制尚不清楚。在本期Cell 中，Sugisawa 等人。证明 ECs 中的 Piezo1 感知来自肠道微生物群的单链 RNA (ssRNA) 以促进血清素的产生。肠上皮中Piezo1 的缺失促进骨形成，减少蠕动，并防止由于血清素减少而导致的结肠炎。