Previous studies have highlighted the importance of considering cognitive functions from a dynamic and interactive perspective and multiple evidence was brought for a language and memory interaction. In this study performed with healthy participants, we present a new protocol entitled GE2REC that interactively accesses the neural representation of language-and-memory network. This protocol consists of three runs related to each other, providing a link between tasks, in order to assure an interactive measure of linguistic and episodic memory processes. GE2REC consists of a sentence generation (GE) in the auditory modality and two recollecting (2REC) memory tasks, one recognition performed in the visual modality, and another one recall performed in the auditory modality. Its efficiency was evaluated in 20 healthy volunteers using a 3T MR imager. Our results corroborate the ability of GE2REC to robustly activate fronto-temporo-parietal language network as well as temporal mesial, prefrontal and parietal cortices in encoding during sentence generation and recognition. GE2REC is useful because it: (a) requires simultaneous and interactive language-and-memory processes and jointly maps their neural basis; (b) explores encoding and retrieval, managing to elicit activation of mesial temporal structures; (c) is easy to perform, hence being suitable for more restrictive settings, and (d) has an ecological dimension of tasks and stimuli. GE2REC may be useful for studying neuroplasticity of cognitive functions, especially in patients with temporal lobe epilepsy who show reorganization of both language and memory networks. Overall, GE2REC can provide valuable information in terms of the practical foundation of exploration language and memory interconnection.

以前的研究强调了从动态和交互的角度考虑认知功能的重要性，并为语言和记忆交互提供了多种证据。在这项对健康参与者进行的研究中，我们提出了一个名为 GE2REC 的新协议，它可以交互访问语言和记忆网络的神经表征。该协议由三个相互关联的运行组成，提供任务之间的链接，以确保语言和情景记忆过程的交互测量。GE2REC 由听觉模态中的一个句子生成 (GE) 和两个回忆 (2REC) 记忆任务组成，一个识别在视觉模态中执行，另一个回忆在听觉模态中执行。使用 3T MR 成像仪在 20 名健康志愿者中评估其效率。我们的结果证实了 GE2REC 在句子生成和识别过程中能够有力地激活额颞顶叶语言网络以及颞内侧、前额叶和顶叶皮质的编码能力。GE2REC 之所以有用，是因为它：(a) 需要同步和交互式的语言和记忆过程，并联合映射它们的神经基础；(b) 探索编码和检索，设法引发内侧颞叶结构的激活；(c) 易于执行，因此适用于更严格的环境，并且 (d) 具有任务和刺激的生态维度。GE2REC 可能有助于研究认知功能的神经可塑性，尤其是在表现出语言和记忆网络重组的颞叶癫痫患者中。全面的，