The intestinal mucosal barrier plays a critical role in the maintenance of host health. In farmed teleost fish, the intestinal epithelium is challenged by a number of factors, leading to damage of the intestinal mucosal barrier. The pathogenesis of intestinal mucosal barrier damage in most farmed teleost fish has been associated with cell death, mainly including apoptosis, pyroptosis, necroptosis as well as secondary injury by cell lysis. However, the mechanisms behind intestinal mucosal barrier damage are not well studied. Here we summarized the factors causing damage of intestinal mucosal barrier in fish. Further we discussed the intracellular and interstitial signaling cascades, with special emphasis on cell death that potentially accelerates the progression of intestinal injury. Deeper understanding of the mechanisms of intestinal mucosal barrier damage may facilitate the development of potential intervention strategies for intestinal diseases in farmed teleost fish.

中文翻译：

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养殖硬骨鱼肠道健康研究进展：肠黏膜屏障及其损伤影响的观点

肠黏膜屏障在维持宿主健康方面起着关键作用。在养殖的硬骨鱼中，肠上皮受到多种因素的挑战，导致肠粘膜屏障受损。大多数养殖硬骨鱼肠黏膜屏障损伤的发病机制与细胞死亡有关，主要包括细胞凋亡、细胞焦亡、坏死以及细胞裂解引起的继发性损伤。然而，肠黏膜屏障损伤背后的机制尚未得到很好的研究。在这里，我们总结了造成鱼肠黏膜屏障受损的因素。我们进一步讨论了细胞内和间质信号级联，特别强调了可能加速肠道损伤进展的细胞死亡。