Abstract

In connection with the development of methods for the delivery of lipophilic drugs in a bioavailable form, we have employed an integrated approach to the investigation of the adsorption of an antihypertensive drug, felodipine, at interfaces that simulate the surfaces of different carriers. Isotherms have been plotted for felodipine adsorption from solutions in heptane (C = 2.13 × 10^–5 − 4.26 × 10^–4 M) at interfaces with water and silver metal, as well as for the compression of drug monolayers formed on a water surface from the heptane solutions. The quantitative characteristics of the studied felodipine layers have been determined, and their phase state and the most probable conformation of adsorbed drug molecules have been analyzed taking into account the data of molecular dynamics simulations. The phase state of the felodipine layers at the heptane/water interface is adequately described by the van Laar equation. A bilayer is formed at the silver surface. A phase transition from a gaseous state to a liquid-expanded state has been revealed for the felodipine layers.

中文翻译：

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亲脂性药物非洛地平在不同界面上的吸附

摘要

随着以生物可利用形式递送亲脂性药物的方法的发展，我们采用了一种综合方法来研究降压药非洛地平在模拟不同载体表面的界面上的吸附。已经绘制了等温线以从庚烷溶液中吸附非洛地平（C = 2.13×10 ^–5 − 4.26×10 ^–4M）与水和银金属的界面，以及用于压缩由庚烷溶液在水表面形成的药物单层。确定了所研究的非洛地平层的定量特征，并考虑了分子动力学模拟数据，分析了它们的相态和最可能吸附的药物分子构象。范拉尔方程充分描述了庚烷/水界面上非洛地平层的相态。在银表面形成双层。对于非洛地平层已经显示出从气态到液态膨胀状态的相变。