A composite material featuring a zirconium-based metal–organic framework and graphene oxide (Zr-MOF@GO) was synthesized by a hydrothermal method and bonded to a stainless steel wire with an inorganic binder as a solid-phase microextraction (SPME) fiber for the derivatization-free extraction and analysis of nonsteroidal anti-inflammatory drugs (NSAIDs) coupled with gas chromatography (GC). The force between the Zr-MOF@GO and NSAIDs includes coordination action, H-bonding, and π–πconjugation effect, which results in the better extraction performance than a commercial polyamide fiber. The developed method achieved low detection limits (0.001–0.030 µg L−1, S/N = 3) and wide linear range (0.01–500 µg L−1) with good linearity (R ≥ 0.9970). The fiber coating had a high scratch resistance, which could effectively prevent coating wear and failure due to the friction between the fiber and the casing. Combined with the high thermal and chemical stability, the loss-free service life of the coating reached at least 240 extractions. Particularly, the derivatization-free extraction technique can greatly reduce the extraction time and use of organic solvents, thus maximizing the SPME technology advantages. It is evident that the analysis method is simple, environmentally friendly, and fast for detecting NSAIDs in water with high efficiency and long service life.

中文翻译：

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一种具有高比表面积的 Zr-MOF@GO 涂层纤维，用于高效、绿色、长寿命的固相微萃取水中的非甾体抗炎药

通过水热法合成了一种以锆基金属-有机骨架和氧化石墨烯为特征的复合材料（Zr-MOF@GO），并用无机粘合剂将其作为固相微萃取（SPME）纤维与不锈钢丝粘合在一起。非甾体抗炎药 (NSAID) 与气相色谱 (GC) 联用的免衍生化提取和分析。Zr-MOF@GO 和 NSAIDs 之间的力包括配位作用、H 键和 π-π 共轭效应，这导致比商业聚酰胺纤维更好的提取性能。开发的方法实现了低检测限 (0.001–0.030 µg L-1, S/N = 3) 和宽线性范围 (0.01–500 µg L-1) 以及良好的线性 (R ≥ 0.9970)。纤维涂层具有很高的抗划伤性，可有效防止因光纤与套管摩擦引起的涂层磨损和失效。结合高热稳定性和化学稳定性，涂层的无损耗使用寿命至少达到 240 次提取。特别是免衍生化萃取技术可以大大减少萃取时间和有机溶剂的使用，从而最大限度地发挥SPME技术的优势。可见，该分析方法简单、环保、快速，可用于检测水中的NSAIDs，效率高，使用寿命长。免衍生萃取技术可以大大减少萃取时间和有机溶剂的使用，从而最大限度地发挥SPME技术优势。可见，该分析方法简单、环保、快速，可用于检测水中的NSAIDs，效率高，使用寿命长。免衍生萃取技术可以大大减少萃取时间和有机溶剂的使用，从而最大限度地发挥SPME技术优势。可见，该分析方法简单、环保、快速，可用于检测水中的NSAIDs，效率高，使用寿命长。