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Expression of SARS-CoV-2 receptor ACE2 and the protease TMPRSS2 suggests susceptibility of the human embryo in the first trimester.
Open Biology ( IF 5.8 ) Pub Date : 2020-08-05 , DOI: 10.1098/rsob.200162
Bailey A T Weatherbee 1 , David M Glover 2, 3 , Magdalena Zernicka-Goetz 1, 3
Affiliation  

While initially recognized as causing respiratory disease, the SARS-CoV-2 virus also affects many other organs leading to other complications. It has emerged that advanced age and obesity are risk factors for complications but questions concerning the potential effects on fetal health and successful pregnancy for those infected with SARS-CoV-2 remain largely unanswered. Here, we examine human pre-gastrulation embryos to determine the expression patterns of the genes ACE2, encoding the SARS-CoV-2 receptor, and TMPRSS2, encoding a protease that cleaves both the viral spike protein and the ACE2 receptor to facilitate infection. We show expression and co-expression of these genes in the trophoblast of the blastocyst and syncytiotrophoblast and hypoblast of the implantation stages, which develop into tissues that interact with the maternal blood supply for nutrient exchange. Expression of ACE2 and TMPRSS2 in these tissues raises the possibility for vertical transmission and indicates that further work is required to understand potential risks to implantation, placental health and fetal health that require further study.



中文翻译:

SARS-CoV-2受体ACE2和蛋白酶TMPRSS2的表达表明人的胚胎在孕早期易感。

尽管最初被认为会引起呼吸系统疾病,但SARS-CoV-2病毒还影响许多其他器官,导致其他并发症。已经表明,高龄和肥胖是并发症的危险因素,但有关SARS-CoV-2感染者对胎儿健康和成功妊娠的潜在影响的问题仍未得到解答。在这里,我们检查了人类妊娠前胚胎,以确定编码SARS-CoV-2受体和TMPRSS2的基因ACE2的表达模式,编码一种蛋白酶,可裂解病毒突触蛋白和ACE2受体以促进感染。我们显示了这些基因在胚泡的滋养层和合胞体滋养层和植入期的亚胚层中的表达和共表达,它们发展成与母体血液供应进行营养交换的组织。ACE2TMPRSS2在这些组织中的表达增加了垂直传播的可能性,并表明需要进一步的工作来了解需要进一步研究的潜在的植入,胎盘健康和胎儿健康风险。

更新日期:2020-08-05
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