The side effects of chemical drugs and multi-drug resistance are serious obstacles hindering efficient tumor therapy. Therefore, recently, the combination of chemo/photothermal therapy (CT/PT) has been adopted to address these issues using a low drug dosage. However, the development of multi-functional drug delivery systems with improved immune escape capability and enhanced drug accumulation at specific tumor tissues is still in its infancy. Herein, polyethylene glycol (PEG)-modified WS₂ nanosheets (WS₂-PEG) were used as a nanocarrier scaffold for doxorubicin (DOX, D) loading and near-infrared fluorescence probe indocyanine green (ICG, I) doping. After surface modification with the erythrocyte membrane (M) and targeted folic acid (FA) molecule, a new biomimetic system (WID@M-FA NPs) with high biocompatibility, prolonged cycle time (3.6-fold longer than WID NPs) and remarkable near-infrared photothermal function was developed for a targeted cervical cancer therapy. The in vitro assay indicated that the photothermal effects caused by ICG upon laser irradiation not only enhanced the cellular uptake of the drug, but also enhanced its tumor cell killing efficiency. Moreover, the targeted accumulation of DOX at the cervical cancer tissue and the synergistic chemo/photothermal therapy finally resulted in tumor elimination to more than 95% without side effects to the normal tissues in vivo. Thus, these excellent preclinical results indicate that WID@M-FA NPs may be an efficient therapeutic modality for the treatment of cervical cancer.

中文翻译：

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具有红细胞膜涂层的聚乙二醇化WS2纳米药物系统，用于宫颈癌的化学/光热疗法。

化学药物的副作用和多药耐药性是阻碍有效肿瘤治疗的严重障碍。因此，近来，化学/光热疗法（CT / PT）的结合已被采用以低药物剂量解决这些问题。然而，具有改善的免疫逃逸能力和增强的在特定肿瘤组织上的药物蓄积的多功能药物递送系统的开发仍处于起步阶段。本文中，聚乙二醇（PEG）修饰的WS ₂纳米片（WS ₂-PEG）用作阿霉素（DOX，D）负载和近红外荧光探针吲哚菁绿（ICG，I）掺杂的纳米载体支架。用红细胞膜（M）和目标叶酸（FA）分子进行表面修饰后，新的仿生系统（WID @ M-FA NPs）具有很高的生物相容性，延长了循环时间（比WID NPs长3.6倍），并且靠近红外光热功能被开发用于靶向宫颈癌治疗。在体外分析表明，ICG在激光照射下引起的光热效应不仅增强了药物对细胞的吸收，而且增强了其杀伤肿瘤细胞的效率。此外，DOX在宫颈癌组织上的靶向蓄积和协同的化学/光热疗法最终导致肿瘤清除率达到95％以上，而对体内正常组织无副作用。因此，这些优异的临床前结果表明，WID @ M-FA NPs可能是治疗宫颈癌的有效治疗方式。