Background. Obstructive sleep apnea (OSA) is closely related to the incidence and progression of coronary artery disease (CAD), and the mechanisms linking OSA and CAD are multifactorial. C1q/TNF-related protein-9 (CTRP9) is a novel adipokine that protects the heart against ischemic injury and ameliorates cardiac remodeling. We aimed to ascertain the clinical relevance of CTRP9 with OSA prevalence in patients with CAD. Methods. From August 2016 to March 2019, consecutive eligible patients with CAD (; angina pectoris, ; acute myocardial infarction [AMI], ) underwent cardiorespiratory polygraphy. OSA was defined as an apnea-hypopnea index (AHI) ≥15 events·h⁻¹. Plasma CTRP9 concentrations were measured by ELISA method. Results. Moderate/severe OSA was present in 89 patients (57.8%). CTRP9 levels were significantly decreased in the moderate/severe OSA group than in the no/mild OSA group (4.7 [4.1-5.2] ng/mL vs. 4.9 [4.4-6.0] ng/mL, ). The difference between groups was only observed in patients with AMI (3.0 [2.3-4.9] vs. 4.5 [3.2-7.9], ). Correlation analysis showed that CTRP9 levels were negatively correlated with AHI (, ) and oxygen desaturation index (, ) and positively correlated with left ventricular ejection fraction (, ) in all subjects. Multivariate analysis showed that male gender (OR 3.099, 95% CI 1.029-9.330, ), BMI (OR 1.148, 95% CI 1.040-1.268, ), and CTRP9 levels (OR 0.726, 95% CI 0.592-0.890, ) were independently associated with the prevalence of moderate/severe OSA. Conclusions. Plasma CTRP9 levels were independently related to the prevalence of moderate/severe OSA in patients with CAD, suggesting that CTRP9 might play a role in the pathogenesis of CAD exacerbated by OSA.

中文翻译：

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C1q/TNF 相关蛋白 9 (CTRP9) 水平与冠状动脉疾病患者阻塞性睡眠呼吸暂停的关系。

背景。阻塞性睡眠呼吸暂停 (OSA) 与冠状动脉疾病 (CAD) 的发生和进展密切相关，而将 OSA 与 CAD 联系起来的机制是多因素的。C1q/TNF 相关蛋白 9 (CTRP9) 是一种新型脂肪因子，可保护心脏免受缺血性损伤并改善心脏重塑。我们旨在确定 CTRP9 与 CAD 患者 OSA 患病率的临床相关性。方法。2016 年 8 月至 2019 年 3 月，连续符合条件的 CAD 患者（; 心绞痛，; 急性心肌梗死 [AMI]，)接受了心肺测谎术。OSA 定义为呼吸暂停-低通气指数 (AHI) ≥15 个事件·h ^-1。通过ELISA方法测量血浆CTRP9浓度。结果。89 名患者 (57.8%) 存在中度/重度 OSA。中/重度 OSA 组的 CTRP9 水平显着低于无/轻度 OSA 组（4.7 [4.1-5.2] ng/mL 对比 4.9 [4.4-6.0] ng/mL，）。仅在 AMI 患者中观察到组间差异（3.0 [2.3-4.9] vs. 4.5 [3.2-7.9]，）。相关分析显示CTRP9水平与AHI呈负相关（, )和氧饱和度指数 (, )并与左心室射血分数 (, )在所有科目中。多变量分析显示，男性（OR 3.099，95% CI 1.029-9.330，), BMI (OR 1.148, 95% CI 1.040-1.268,)和 CTRP9 水平 (OR 0.726, 95% CI 0.592-0.890,)与中度/重度 OSA 的患病率独立相关。结论。血浆 CTRP9 水平与 CAD 患者中重度 OSA 的患病率独立相关，提示 CTRP9 可能在 OSA 加重的 CAD 发病机制中发挥作用。