Asthma development and persistence is tightly linked to respiratory viruses. Viral presence is usually interrogated with targeted approaches during periods of disease activity and/or infections, thus neglecting viral occurrence during steady states. We investigate the virome in the upper respiratory system of healthy and asthmatic preschool children during asymptomatic/non-infection periods using metagenomics. Children with asthma have a characteristically dysbiotic virome that correlates to disease severity and control. The major component of dysbiosis is bacteriophage deficiency, while eukaryotic viral presence is increased. At the metacommunity level, differential virus species co-occurrence patterns suggest a decrease of the microbiota community resilience in asthma. Viral dysbiosis is therefore a key characteristic of asthma pathophysiology.

中文翻译：

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噬菌体缺乏是儿童哮喘中呼吸道病毒性营养不良的特征

哮喘的发展和持续性与呼吸道病毒紧密相关。在疾病活动和/或感染期间，通常以靶向方法来询问病毒的存在，从而忽略了稳定状态下的病毒发生。我们使用宏基因组学研究了无症状/无感染期间健康和哮喘学龄前儿童上呼吸道中的病毒。哮喘患儿的典型的不良生物病毒血症与疾病的严重程度和控制能力有关。营养不良的主要成分是噬菌体缺乏，而真核病毒的存在增加了。在元社区水平上，不同的病毒物种共存模式表明哮喘中微生物群落的适应力下降。因此，病毒性营养不良是哮喘病理生理学的关键特征。