ConoMode is a database for complex three-dimensional (3D) structures of conopeptides binding with their target proteins. Conopeptides, a large family of peptides from the venom of marine snails of the Conus genus, have exceptionally diverse sequences, and their high specificity to block ion channels makes them crucial as drug leads and tools for physiological studies. ConoMode is a specialized archive for the collection of 3D coordinate data for the conopeptides and their binding target proteins from published literature and the Protein Data Bank. These 3D structures can be determined using experimental methods such as X-ray crystallography and electron microscopy and computational methods including docking, homology modeling and molecular dynamics simulations. The binding modes for the conopeptides determined using computational modeling must be validated based on experimental data. The 3D coordinate data from ConoMode can be searched, visualized, downloaded and uploaded. Currently, ConoMode manages 19 conopeptide sequences (from 10 Conus species), 15 protein sequences and 37 3D structures. ConoMode utilizes a modern technical framework to provide a good user experience on mobile devices with touch interaction features. Furthermore, the database is fully optimized for unstructured data and flexible data models.

中文翻译：

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ConoMode，用于肽段结合模式的数据库。

ConoMode是一个数据库，用于连接与目标蛋白结合的复杂的三维肽（3D）结构。Conopepteptides，来自圆锥形海洋蜗牛毒液的一大类肽属，具有异常多样的序列，其对离子通道的高特异性使其成为药物研究的先导和重要工具。ConoMode是一个专门的档案库，用于从已出版的文献和蛋白质数据库中收集有关肽和其结合靶蛋白的3D坐标数据。可以使用实验方法（例如X射线晶体学和电子显微镜）以及包括对接，同源性建模和分子动力学模拟在内的计算方法来确定这些3D结构。必须基于实验数据验证使用计算模型确定的conopepteptes的结合模式。可以搜索，可视化，下载和上传来自ConoMode的3D坐标数据。目前，ConoMode管理着19个肽段序列（从10个圆锥体），15个蛋白质序列和37个3D结构。ConoMode利用现代技术框架在具有触摸交互功能的移动设备上提供良好的用户体验。此外，该数据库针对非结构化数据和灵活的数据模型进行了全面优化。