Fcɣ receptors (FcɣRs) are key immune regulatory receptors that connect antibody-mediated immune responses to cellular effector functions. They are involved in the control of various immune functions including responses to infections. Genetic polymorphisms of FcɣRs coding genes (FCGR) have been associated with the regulation of HIV infection and progression. In this study, we analyzed the potential impact of five candidate FcɣR SNPs on viral control by genotyping 251 HIV controllers and 250 progressors. The rs10800309 AA genotype of the FcɣRIIa coding gene FCGR2A was found to be significantly associated with HIV control and this association was independent of HLA-B57 and HLA-B27 (OR, 2.84; 95% CI, 1.20–6.89; P_cor = 0.033). We further confirmed the functional role of this polymorphism by showing an association of this same AA genotype with an increased in vitro FcɣRII expression on myeloid cells including dendritic cells (P = 0.0032). Together, these results suggest that the AA genotype of rs10800309 confers an improved immune response through FcɣRII upregulation and that this polymorphism may serve as an additional predictive marker of HIV control.

Fcγ受体（FcγR）是关键的免疫调节受体，其将抗体介导的免疫反应与细胞效应子功能联系起来。它们参与各种免疫功能的控制，包括对感染的反应。FcɣRs编码基因（基因多态性FCGR）已经被与HIV感染和进展的调节相关联。在这项研究中，我们通过对251个HIV控制者和250个进展者进行基因分型，分析了5个候选FcɣRSNP对病毒控制的潜在影响。发现FcɣRIIa编码基因FCGR2A的rs10800309 AA基因型与HIV控制显着相关，并且这种相关独立于HLA-B57和HLA-B27（OR，2.84； 95％CI，1.20-1.69；P_cor  = 0.033）。我们通过显示相同的AA基因型与包括树突状细胞在内的髓样细胞的体外FcIIRII表达增加相关联，进一步证实了这种多态性的功能作用（P  = 0.0032）。总之，这些结果表明，rs10800309的AA基因型可通过FcɣRII上调赋予改善的免疫反应，并且该多态性可作为HIV控制的另一预测指标。