Abstract

This study investigated the effect of eight weeks of aerobic training (AT) combined with silymarin (S)consumption on glycemic indices and liver enzymes in men with type 2 diabetes (T2D). In this clinical trial, 60 middle-aged male volunteers were randomly divided into 4 groups, including: (1) C + placebo(C) (2) AT + placebo (3), S and (4) AT + S. AT was performed for eight weeks, three sessions per week, each session for 20–45 minutes at an intensity of 60–85% of maximal heart rate reserve, and S receiving groups consumed 140 mg/kg S daily (in two servings). AT reduced glycemic indices and liver enzymes in men with T2D (p ≤ .05). S decreased blood glucose, insulin, HOMA-IR, AST, ALT and ALP in men with T2D (p ≤ .05). Exercise along with silymarin decreased blood glucose, insulin, HOMA-IR, AST, ALT and ALP. Also, reduction of AST and blood glucose in the AT + S group was more favourable than the effect of S alone (p ≤ .05). It seems that simultaneous AT and S has interactive effects on reducing glycemic indices and liver enzymes in men with T2D.

摘要

本研究调查了八周的有氧训练 (AT) 结合水飞蓟素 (S) 摄入对 2 型糖尿病 (T2D) 男性血糖指数和肝酶的影响。在这项临床试验中，60 名中年男性志愿者被随机分为 4 组，包括：（1）C + 安慰剂（C）（2）AT + 安慰剂（3）S 和（4）AT + S。进行八周，每周 3 次，每次 20-45 分钟，强度为最大心率储备的 60-85%，S 接受组每天消耗 140 mg/kg S（分两次）。AT 降低了患有 T2D 的男性的血糖指数和肝酶 ( p  ≤ .05)。S 降低了患有 T2D 的男性的血糖、胰岛素、HOMA-IR、AST、ALT 和 ALP（p ≤ .05)。与水飞蓟素一起运动可降低血糖、胰岛素、HOMA-IR、AST、ALT 和 ALP。此外，AT + S 组中 AST 和血糖的降低比单独使用 S 的效果更有利 ( p  ≤ .05)。似乎同时服用 AT 和 S 对降低患有 T2D 的男性的血糖指数和肝酶具有交互作用。