Abstract

Purpose

Previous literature has shown that standing stability relies on the vestibular system; however, the neural correlates underlying standing stability remains unclear. This study aimed to investigate the neural correlates of standing stability using functional magnetic resonance imaging (fMRI) following galvanic vestibular stimulation (GVS).

Materials and methods

Forty-five healthy right-handed healthy volunteers were included. Postural stability was measured using the modified Clinical Test of Sensory Interaction and Balance (mCTSIB), which measures swaying speed and area on hard and soft surfaces when the volunteer’s eyes are open and closed. Functional activation as determined by the blood oxygenation level-dependent (BOLD) response, was measured during GVS using fMRI. We investigated the association between BOLD responses during GVS and postural stability.

Results

Relative to rest, participants showed significantly higher BOLD signal during GVS in the parietal operculum, central operculum, and the opercular part of the inferior frontal gyrus. Moreover, functional activation in the central operculum was negatively correlated with standing stability, indexed using swaying speed when volunteers stood on a foam surface with their eyes closed.

Conclusions

Our findings suggest that the neural correlates of standing stability involve greater functional activation in the central operculum.

中文翻译：

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电前庭刺激期间更大的功能激活与改善的姿势稳定性有关：GVS-fMRI 研究。

摘要

目的

先前的文献表明，站立稳定性依赖于前庭系统；然而，潜在站立稳定性的神经相关性仍不清楚。本研究旨在研究前庭电刺激 (GVS) 后使用功能性磁共振成像 (fMRI) 与站立稳定性的神经相关性。

材料和方法

包括 45 名健康的右手健康志愿者。使用改进的感官相互作用和平衡临床测试 (mCTSIB) 测量姿势稳定性，该测试测量当志愿者睁眼和闭眼时在硬和软表面上的摇摆速度和面积。在 GVS 期间使用 fMRI 测量由血氧水平依赖性 (BOLD) 反应确定的功能激活。我们调查了 GVS 期间 BOLD 反应与姿势稳定性之间的关联。

结果

相对于休息，参与者在 GVS 期间在顶叶鳃盖、中央鳃盖和额下回的鳃盖部分显示出显着更高的 BOLD 信号。此外，中央鳃盖的功能激活与站立稳定性呈负相关，当志愿者闭上眼睛站在泡沫表面上时，使用摇摆速度进行索引。

结论

我们的研究结果表明，站立稳定性的神经相关性涉及中央鳃盖中更大的功能激活。