ABSTRACT

RNA-binding proteins regulate RNA fate and govern post-transcriptional gene regulation. A new family of RNA-binding proteins is represented by regulatory RNases (Regnase, also known as Zc3h12 or MCPIP), which have emerged as important players in immune homoeostasis. Four members, Regnase1-4, have been identified to date. Here we summarize recent findings on the role of Regnase in the regulation of RNA biology and its consequences for cell functions and inflammatory processes.

中文翻译：

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Regnase 家族 RNA 结合蛋白的免疫调节作用。

摘要

RNA 结合蛋白调节 RNA 命运并控制转录后基因调控。一个新的 RNA 结合蛋白家族以调节性 RNase（Regnase，也称为 Zc3h12 或 MCPIP）为代表，它们已成为免疫稳态的重要参与者。迄今为止，已经确定了四个成员，即 Regnase1-4。在这里，我们总结了最近关于 Regnase 在 RNA 生物学调节中的作用及其对细胞功能和炎症过程的影响的发现。