Abstract

Phthalate esters are produced widely for their use as plasticizer in consumer products such as cosmetics, PVC, deodorants etc. Their use is considered harmless but they are known to induce cancer and work as endocrine disruptors. In this review, we try to emphasize the ubiquitous presence of phthalate esters and the pathways they affect to induce, metastasizes cancer or to prompt drug resistance in cancer cells. We reviewed the literature from the last one decade on PubMed. The keywords used were ‘Phthalates’ ‘Breast cancer’ ‘endocrine disruptors’ ‘environmental carcinogens’ ‘Phthalates and reproductive health’ etc. In conclusion, the phthalates are able to mimic estrogen, to prompt proliferation, metastasis and drug resistance in breast cancer cells. The data for its dosage exposure to induce ill-effects remains largely inconsistent. The only well researched molecular target of phthalate is Aryl hydrocarbon receptor (AhR) which is a ligand activated transcription factor. Being an interesting and important problem of research this aspect had not been touched in the way as it has to be.

摘要

邻苯二甲酸酯被广泛生产，用作化妆品、PVC、除臭剂等消费品中的增塑剂。它们的使用被认为是无害的，但已知它们会诱发癌症并用作内分泌干扰物。在这篇综述中，我们试图强调无处不在的邻苯二甲酸酯及其影响诱导、转移癌症或促使癌细胞产生耐药性的途径。我们回顾了过去十年在 PubMed 上的文献。使用的关键词是“邻苯二甲酸盐”“乳腺癌”“内分泌干扰物”“环境致癌物”“邻苯二甲酸盐与生殖健康”等。总之，邻苯二甲酸盐能够模拟雌激素，促进乳腺癌细胞的增殖、转移和耐药性. 其剂量暴露以引起不良影响的数据在很大程度上仍然不一致。邻苯二甲酸酯唯一经过充分研究的分子靶标是芳烃受体 (AhR)，它是一种配体激活的转录因子。作为一个有趣且重要的研究问题，这方面并没有以它必须的方式被触及。