Abstract This systematic review aimed to discuss the effects of arginine on caries-related microorganisms in different in vitro biofilm models. The eligibility criteria were in vitro studies that evaluated the effect of arginine at different concentrations on caries-related microorganisms using biofilm models. Eighteen studies published between 2012 and 2019 were included. Different bacterial species were studied. Seventeen studies (94.4%) achieved a low risk of bias and only one showed a medium risk of bias. The studies showed that arginine is a promising approach for the ecological management of dental caries. The focus of this review was to evaluate the effects of arginine on microorganisms involved in the mechanism of dental caries.

中文翻译：

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精氨酸对参与龋齿的微生物的影响：体外研究的系统文献综述

摘要 本系统评价旨在讨论精氨酸在不同体外生物膜模型中对龋齿相关微生物的影响。资格标准是体外研究，该研究使用生物膜模型评估不同浓度的精氨酸对龋齿相关微生物的影响。纳入了 2012 年至 2019 年间发表的 18 项研究。研究了不同的细菌种类。17 项研究 (94.4%) 的偏倚风险较低，只有一项研究显示偏倚风险中等。研究表明，精氨酸是一种很有前途的龋齿生态管理方法。本综述的重点是评估精氨酸对参与龋齿机制的微生物的影响。