Cognitive training (CT) shows modest positive effects on cognitive function in patients with Parkinson’s disease (PD). Gamification may enhance adherence to traditional CT, but this has not been studied yet. Here, we investigated the feasibility of a gamified CT. We performed a randomized controlled trial including PD patients with mild cognitive impairment. Participants were randomly allocated to a 12-week home-based gamified CT intervention or waiting-list control group. Assessments were performed at baseline and at weeks 12 and 24. Forty-one patients were included (21 intervention and 20 waiting-list controls). Sixty-three percent of the intervention group trained >50% of the recommended sessions, while 81% voluntarily continued training after 12 weeks. After 24 weeks, 87.5% graded the game to be satisfactory. Global cognition scores improved after 24 weeks. Home-based gamified CT shows acceptable feasibility in patients with PD, and we observed preliminary indications for efficacy. Larger trials are needed to establish this efficacy.

中文翻译：

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帕金森病认知训练游戏的可行性：随机帕金森游戏研究

认知训练 (CT) 显示出对帕金森病 (PD) 患者认知功能的适度积极影响。游戏化可能会增强对传统 CT 的依从性，但这尚未得到研究。在这里，我们研究了游戏化 CT 的可行性。我们进行了一项随机对照试验，包括轻度认知障碍的 PD 患者。参与者被随机分配到一个为期 12 周的家庭游戏化 CT 干预组或等候名单对照组。在基线和第 12 周和第 24 周进行评估。包括 41 名患者（21 名干预和 20 名等待名单对照）。63% 的干预组训练了超过 50% 的推荐课程，而 81% 的人在 12 周后自愿继续训练。24 周后，87.5% 的玩家认为游戏令人满意。24 周后，全球认知评分有所改善。基于家庭的游戏化 CT 在 PD 患者中显示出可接受的可行性，我们观察到了初步疗效适应症。需要更大规模的试验来确定这种功效。