Skin wound healing shows an extraordinary cellular function mechanism, unique in nature and involving the interaction of several cells, growth factors and cytokines. Physiological wound healing restores tissue integrity, but in many cases the process is limited to wound repair. Ongoing studies aim to obtain more effective wound therapies with the intention of reducing inpatient costs, providing long-term relief and effective scar healing. The main goal of this comprehensive review is to focus on the progress in wound medication and how it has evolved over the years. The main complications related to the healing process and the clinical management of chronic wounds are described in the review. Moreover, advanced treatment strategies for skin regeneration and experimental techniques for cellular engineering and skin tissue engineering are addressed. Emerging skin regeneration techniques involving scaffolds activated with growth factors, bioactive molecules and genetically modified cells are exploited to overcome wound healing technology limitations and to implement personalized therapy design.

中文翻译：

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皮肤伤口愈合过程和新兴的皮肤伤口护理和再生技术。

皮肤伤口愈合显示出非凡的细胞功能机制，其性质独特，并且涉及几种细胞，生长因子和细胞因子的相互作用。生理伤口愈合可恢复组织完整性，但在许多情况下，该过程仅限于伤口修复。正在进行的研究旨在获得更有效的伤口疗法，以减少住院费用，提供长期的缓解和有效的疤痕愈合。这项全面审查的主要目标是着眼于伤口药物的进展及其多年来的发展。该综述描述了与慢性伤口愈合过程和临床处理有关的主要并发症。此外，提出了用于皮肤再生的先进治疗策略以及用于细胞工程和皮肤组织工程的实验技术。