Abstract

An efficient and straightforward Brønsted acid mediated (3+2)-annulation of (aza)-para-quinone methides, generated in situ from propargylic alcohols and indoles, has been developed involving 1,8-conjugate addition/5-endo annulation cascade. This protocol affords a mild and effective method for the construction of synthetically important and structurally interesting functionalized pyrrolo[1,2-a]indoles.

中文翻译：

---

通过（3 + 2）-（Aza）-对-醌醌甲基吲哚的（3 + 2）合成吡咯并[1,2-a]吲哚

摘要

介导的高效和简单的布朗斯台德酸（3 + 2）的（氮杂）-annulation -对-quinone甲基化物，从炔丙醇和吲哚在原位产生的，已经开发了涉及1,8-共轭加成/ 5-内切环级联。该协议提供了一种温和而有效的方法，用于构建具有重要合成意义的重要结构化吡咯并[1,2- a ]吲哚。