The use of non‐human animal models for infection experiments is important for investigating the infectious processes of human pathogenic bacteria at the molecular level. Mammals, such as mice and rabbits, are also utilized as animal infection models, but large numbers of animals are needed for these experiments, which is costly, and fraught with ethical issues. Various non‐mammalian animal infection models have been used to investigate the molecular mechanisms of various human pathogenic bacteria, including Staphylococcus aureus, Streptococcus pyogenes, and Pseudomonas aeruginosa. This review discusses the desirable characteristics of non‐mammalian infection models and describes recent non‐mammalian infection models that utilize Caenorhabditis elegans, silkworm, fruit fly, zebrafish, two‐spotted cricket, hornworm, and waxworm.

中文翻译：

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使用非哺乳动物的动物感染模型。

将非人类动物模型用于感染实验对于从分子水平研究人类病原菌的感染过程非常重要。哺乳动物，例如小鼠和兔子，也被用作动物感染模型，但是这些实验需要大量的动物，这是昂贵的并且充满道德问题。各种非哺乳动物的动物感染模型已用于研究各种人类致病细菌的分子机制，包括金黄色葡萄球菌，化脓性链球菌和铜绿假单胞菌。这篇综述讨论了非哺乳动物感染模型的理想特征，并描述了利用非哺乳动物感染模型的最新非哺乳动物感染模型。秀丽隐杆线虫，蚕，果蝇，斑马鱼，two两点、,和蜡虫。