β3‐αC loop is a highly conserved structural domain across oncogene families, which is a switch for kinase activity. There have been numerous researches on mutations within β3‐αC loop in EGFR, but relatively less in ERBB2, BRAF, and MAP2K1. In addition, previous studies mainly focus on β3‐αC deletion in EGFR, which is the most common type affecting kinase activity and driving lung cancer. Other mutation types are not well studied.

中文翻译：

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EGFR / ERBB2 / BRAF / MAP2K1的β3-αC环内的致癌突变可预测对治疗的反应。

β3-αC环是癌基因家族中一个高度保守的结构域，是激酶活性的开关。已经有在β3-αC环中的突变大量研究EGFR，但相对较少ERBB2，BRAF和MAP2K1。此外，先前的研究主要集中在EGFR中的β3-αC缺失上，这是影响激酶活性并引发肺癌的最常见类型。其他突变类型还没有得到很好的研究。