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The effects of chard on brain damage in valproic acid-induced toxicity.
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-08-04 , DOI: 10.1111/jfbc.13382
Sevim Tunali 1 , Esra Sule Cimen 1 , Refiye Yanardag 1
Affiliation  

Valproic acid (VPA; 2‐propyl valeric acid) is a potent drug widely used in treating anxiety disorders, migraine as well as epileptic diseases. In the ongoing study chard protective effect was investigated, on the damaged VPA rat brain. Sprague Dawley rats (females) were grouped as follows: control, VPA (500 mg kg−1 day−1 VPA intraperitoneal), chard (100 mg/kg day chard extract by gavage), VPA + chard (500 mg kg−1 day−1 VPA + 100 mg kg−1 day−1 chard extract). Aqueous chard leaves extract was given 1 hr before apply VPA for a period of 7 days. Lipid peroxidation, advanced oxidation protein products and protein carbonyl content, and superoxide dismutase, glutathione peroxidase, glutathione‐S‐transferase, and glutathione reductase activities increased in the VPA group. Reduced glutathione levels, paraoxanase, and acetylcholinesterase activities were significantly diminished in the VPA animals. Chard extract application curatively reverted the studied biochemical parameters. The results obtained, it has been found the chard has a protective and antioxidant effect on brain damage induced by VPA.

中文翻译:


甜菜对丙戊酸引起的毒性脑损伤的影响。



丙戊酸(VPA;2-丙基戊酸)是一种有效的药物,广泛用于治疗焦虑症、偏头痛和癫痫病。在正在进行的研究中,研究了甜菜对受损 VPA 大鼠大脑的保护作用。 Sprague Dawley 大鼠(雌性)分组如下:对照、VPA(500 mg kg -1-1 VPA 腹腔注射)、甜菜(100 mg/kg 天甜菜提取物,通过管饲)、VPA + 甜菜(500 mg kg -1天) −1 VPA + 100 mg kg −1−1甜菜提取物)。在施用 VPA 前 1 小时给予水性甜菜叶提取物,持续 7 天。 VPA 组的脂质过氧化、高级氧化蛋白质产物和蛋白质羰基含量以及超氧化物歧化酶、谷胱甘肽过氧化物酶、谷胱甘肽-S-转移酶和谷胱甘肽还原酶活性增加。 VPA 动物中谷胱甘肽水平降低,对恶烷酶和乙酰胆碱酯酶活性显着降低。甜菜提取物的应用可有效地恢复所研究的生化参数。所得结果发现,甜菜对VPA引起的脑损伤具有保护和抗氧化作用。
更新日期:2020-10-11
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