Effect of fish oil and telmisartan on dehydroepiandrosterone‐induced polycystic ovarian syndrome in rats: The role of oxidative stress, transforming growth factor beta‐1, and nuclear factor kappa B,Food Science & Nutrition

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Effect of fish oil and telmisartan on dehydroepiandrosterone‐induced polycystic ovarian syndrome in rats: The role of oxidative stress, transforming growth factor beta‐1, and nuclear factor kappa B
Food Science & Nutrition ( IF 3.5 ) Pub Date : 2020-08-05 , DOI: 10.1002/fsn3.1819
Ahmed M Kabel _{1,

2} , Ahmed M Ashour ₃ , Mohamed S Omar ₄ , Remon S Estfanous ₅

Affiliation

Our aim was to explore the effect of telmisartan and/or fish oil on dehydroepiandrosterone (DHEA)‐induced PCOS in rats. Sixty female rats were divided into six equal groups as follows: Control; DHEA‐induced PCOS; DHEA + Telmisartan; DHEA + Fish oil; DHEA + Carboxymethyl cellulose; and DHEA + Telmisartan +Fish oil group. Plasma sex hormones, anthropometric measurements, and the glycemic indices were measured. Tissue oxidative stress parameters and the proinflammatory cytokines were assessed. The ovaries were subjected to histopathological and electron microscopic examination. Telmisartan and/or fish oil induced significant improvement of insulin resistance with amelioration of oxidative stress and inflammation compared to PCOS group. Also, telmisartan and/or fish oil restored the hormonal levels and the anthropometric measurements to the normal values. This was significant with telmisartan/fish oil combination compared to the use of each of these agents alone. In conclusion, this combination may represent a promising hope for amelioration of PCOS.

中文翻译：

鱼油和替米沙坦对脱氢表雄酮诱导的大鼠多囊卵巢综合征的影响：氧化应激、转化生长因子β-1和核因子κB的作用

我们的目的是探讨替米沙坦和/或鱼油对脱氢表雄酮 (DHEA) 诱导的大鼠 PCOS 的影响。将60只雌性大鼠分为如下6个相等的组：对照组； DHEA 诱发的 PCOS； DHEA+替米沙坦； DHEA+鱼油； DHEA+羧甲基纤维素；以及DHEA+替米沙坦+鱼油组。测量血浆性激素、人体测量值和血糖指数。评估组织氧化应激参数和促炎细胞因子。对卵巢进行组织病理学和电子显微镜检查。与 PCOS 组相比，替米沙坦和/或鱼油可显着改善胰岛素抵抗，并改善氧化应激和炎症。此外，替米沙坦和/或鱼油使荷尔蒙水平和人体测量值恢复到正常值。与单独使用这些药物中的每一种相比，替米沙坦/鱼油组合的这一点非常显着。总之，这种组合可能代表着改善多囊卵巢综合症的希望。

更新日期：2020-09-20

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