Key Laboratory of Experimental Marine BiologyInstitute of OceanologyChinese Academy of Sciences Nanhai Road 7 Qingdao 266071 P. R. China
Laboratory of Marine Biology and BiotechnologyQingdao National Laboratory for Marine Science and Technology Wenhai Road 1 Qingdao 266237 P. R. China
University of Chinese Academy of Sciences Yuquan Road 19 A Beijing 100049 P. R. China
Center for Ocean Mega-ScienceChinese Academy of Sciences Nanhai Road 7 Qingdao 266071 P. R. China
Front Cover. The extreme environment in the deep sea led to the presence of a characteristic thriving world of microbial diversity. With the development of sampling techniques, fungi derived from deep sea (> 1000 m) have attracted considerable attention on account of special biological diversity and prolific metabolisms. Epicoccum nigrum SD‐388 is a deep‐sea‐sediment‐derived fungus with characteristic metabolites of thiodiketopiperazine derivatives (TDKPs), which displays a variety of bioactivities. Systematical isolation of the culture extract resulted in the isolation of two new TDKPs, namely 7‐dehydroxyepicoccin H (1) and 7‐hydroxyeutypellazine F (2), along with seven known TDKP analogs. Significant inhibitory activities of these compounds against aquatic pathogens Vibrio vulnificus, V. alginolyticus, and Edwardsiella tarda were observed, as reported by Wang et al. in their full paper at10.1002/cbdv.202000320.
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