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Front Cover: New Antibacterial Thiodiketopiperazines from the Deep Sea Sediment‐Derived Fungus Epicoccum nigrum SD‐388 (C&B 8/2020)
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2020-08-05 , DOI: 10.1002/cbdv.202000623
Lu‐Ping Chi 1, 2, 3 , Xiao‐Ming Li 1, 2 , Xin Li 1, 2 , Bin‐Gui Wang 1, 2, 4
Affiliation  

Front Cover. The extreme environment in the deep sea led to the presence of a characteristic thriving world of microbial diversity. With the development of sampling techniques, fungi derived from deep sea (> 1000 m) have attracted considerable attention on account of special biological diversity and prolific metabolisms. Epicoccum nigrum SD‐388 is a deep‐sea‐sediment‐derived fungus with characteristic metabolites of thiodiketopiperazine derivatives (TDKPs), which displays a variety of bioactivities. Systematical isolation of the culture extract resulted in the isolation of two new TDKPs, namely 7‐dehydroxyepicoccin H (1) and 7‐hydroxyeutypellazine F (2), along with seven known TDKP analogs. Significant inhibitory activities of these compounds against aquatic pathogens Vibrio vulnificus, V. alginolyticus, and Edwardsiella tarda were observed, as reported by Wang et al. in their full paper at10.1002/cbdv.202000320.
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中文翻译:

封面:深海沉积物衍生的真菌黑短Epi SD‐388的新型抗菌噻二酮哌嗪(C&B 8/2020)

前盖。深海中的极端环境导致了微生物多样性的蓬勃发展。随着采样技术的发展,由于特殊的生物多样性和丰富的新陈代谢,深海(> 1000 m)衍生的真菌引起了极大的关注。Epicoccum nigrum SD‐388是一种深海沉积物衍生的真菌,具有硫代二酮哌嗪衍生物(TDKPs)的特征代谢产物,具有多种生物活性。系统地分离培养物提取物导致分离出两个新的TDKP,即7-脱羟基表霉素H(1)和7-羟基大黄素F(2),以及七个已知的TDKP类似物。如Wang等人所报道,观察到这些化合物对水生病原体的显着抑制活性,如弧菌弧菌溶藻弧菌塔氏爱德华氏菌。在他们的全文中at10.1002 / cbdv.202000320。
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更新日期:2020-08-05
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