A series of benzamide-dioxoisoindoline derivatives 3 was obtained, starting from phthalic anhydride and different benzoyl hydrazides 2, by ultrasound irradiation in water as solvent and without any catalyst. Five obtained compounds have been reported in this study for the first time and crystal structure of compound 3h was determined. All compounds were subjected to experimental determination of their antioxidative potential. DPPH test revealed that newly synthesized phenolic compounds 3d, 3e, and 3j are the best antioxidants. Additionally, probable radical scavenging pathway was analysed for reactions of the most active compounds and some radicals that can be found in living cells.

以邻苯二甲酸酐和不同的苯甲酰肼2为原料，通过在水中作为溶剂进行超声辐照而无需任何催化剂，获得了一系列苯甲酰胺-二氧代异吲哚啉衍生物3。该研究首次报道了五种获得的化合物，并确定了化合物3h的晶体结构。所有化合物均经过实验测定其抗氧化能力。DPPH测试表明，新合成的酚类化合物3d，3e和3j是最好的抗氧化剂。此外，分析了可能的自由基清除途径，以分析活性最高的化合物与活细胞中发现的某些自由基的反应。