The genotype of apolipoprotein E (APOE) is closely associated with susceptibility to Alzheimer's disease. Here, we described the generation and characterization of human induced pluripotent stem cells from peripheral blood mononuclear cells (PBMCs) of a 79-year-old female patient with Alzheimer's disease having APOE3/4 genotype. The generated iPSCs expressed pluripotent stem cell markers that were observed using immunocytochemistry. Moreover, they displayed a normal karyotype and had the potential to differentiate spontaneously into three germ layers in vitro. Our model could provide valuable insights into pathological mechanisms, and offer a unique opportunity for developing drugs against specific phenotypes for Alzheimer's disease therapy.

载脂蛋白E（APOE）的基因型与阿尔茨海默氏病的易感性密切相关。在这里，我们描述了79岁的患有APOE3 / 4基因型阿尔茨海默氏病女性患者外周血单核细胞（PBMC）的人诱导多能干细胞的生成和表征。生成的iPSC表达了多能干细胞标记，可通过免疫细胞化学观察到。此外，它们显示出正常的核型，并具有在体外自发分化为三个胚层的潜力。我们的模型可以为病理机制提供有价值的见解，并为开发针对特定表型的药物提供独特的机会，以治疗阿尔茨海默氏病。