The association in aqueous mixtures of a thermoresponsive cationic diblock copolymer composed of poly(N-isopropylacrylamide) (PNIPAM) and poly(3-acrylamidopropyl)-trimethylammonium-chloride (PAMPTMA(+)) and the oppositely charged bile salt sodium deoxycholate (NaDC) is investigated at different compositions by light and X-ray scattering, calorimetry and electrophoretic mobility measurements. Clouding reveals aggregation upon heating. The addition of NaDC to the copolymer solution lowers the temperature of the transition and increases its cooperativity. At high temperature and low NaDC fractions, mixed aggregates with a dehydrated PNIPAM-rich interior and a PAMPTMA(+)-rich shell partially neutralized by DC^– anions are formed. At high NaDC fractions, the aggregates present internal regularly spaced segregated nanoregions of dehydrated PNIPAM and PAMPTMA(+)/DC^– (microphase separation). The results suggest that the mixed aggregates have appealing composition-controlled thermoresponse. The system phase separates at body temperature and the highest NaDC fractions investigated, meaning in conditions accomplished when the use of the polymer as a bile salt sequestrant is hypothesized.

由聚（N-异丙基丙烯酰胺）（PNIPAM）和聚（3-丙烯酰胺基丙基）-三甲基氯化铵（PAMPTMA（+））组成的热响应性阳离子二嵌段共聚物与带相反电荷的胆盐脱氧胆酸钠（NaDC）在水性混合物中的缔合通过光和X射线散射，量热法和电泳迁移率测量研究了不同组成下的。混浊表明加热时聚集。向共聚物溶液中添加NaDC可以降低转变温度并提高其协同作用。在高温和低NaDC馏分下，混合的骨料具有富含PNIPAM的脱水内部和被DC部分中和的富含PAMPTMA（+）的壳^–形成阴离子。在高NaDC分数下，聚集体存在脱水PNIPAM和PAMPTMA（+）/ DC ^–（微相分离）的内部规则隔开的纳米区域。结果表明，混合骨料具有有吸引力的成分控制的热响应。系统相在体温和最高的NaDC馏分下分离，这意味着在假设将聚合物用作胆盐螯合剂时所达到的条件下。