At present, the etiology and pathogenesis of major depressive disorder(MDD) are still unclear. Some studies have shown that toll-like receptor 4 may play an important role in MDD. However, little is currently known about the association between TLR4 single gene polymorphisms (SNPs) and depressive symptoms and antidepressant efficacy.The aim of this study is to analyze whether TLR4 SNPs are associated with depressive symptoms and antidepressant efficacy. The study consisted of 438 patients with first-episode depression. We analyzed three TLR4 SNPs (rs1927911, rs11536889, and rs7873784) and obtained the baseline and 6-week scores using the 17-item Hamilton Depression Rating Scale (HAMD17) and its five-factor model. Allelic and genotypic association tests between TLR4 SNPs and HAMD17 total and cluster scores were performed with UNPHASED, while chi-square tests to analyze the association between TLR4 SNPs and response to antidepressants were performed with SPSS. Patients with the rs1927911-GG genotype exhibited higher scores of anxiety (physical symptoms) and anxiety (somatic). Patients with rs1927911-G also exhibited higher anxiety (physical symptoms) and anxiety (somatic) scores. Patients with rs11536889-GG had significantly lower suicide scores and higher psychomotor retardation scores. Patients with rs11536889-G also had significantly lower suicide scores and higher psychomotor retardation scores. Patients with rs7873784-G had higher anxiety (physical symptoms) and anxiety (psychological) scores. There was no significant difference between antidepressant efficacy and TLR4 gene polymorphisms. These findings provide evidence that TLR4 plays an important role in anxiety, suicide, and other symptoms in patients with MDD. No relationship was found between TLR4 gene polymorphisms and antidepressant efficacy in this study. Further research is needed on gene polymorphisms and the expression of TLR4 in patients with MDD.

目前，尚不清楚主要抑郁症的病因和发病机制。一些研究表明，收费型受体4可能在MDD中起重要作用。然而，关于TLR4单基因多态性（SNP）与抑郁症状和抗抑郁药疗效之间的关联目前知之甚少。本研究的目的是分析TLR4 SNP是否与抑郁症状和抗抑郁药疗效有关。该研究由438名首发抑郁症患者组成。我们分析了三个TLR4 SNP（rs1927911，rs11536889和rs7873784），并使用17个项的汉密尔顿抑郁评估量表（HAMD17）及其五因素模型获得了基线和6周得分。使用UNPHASED进行了TLR4 SNP与HAMD17总分和聚类得分之间的等位基因和基因型关联测试，而SPSS则进行卡方检验，以分析TLR4 SNP与抗抑郁药反应之间的关系。rs1927911-GG基因型患者表现出较高的焦虑（身体症状）和焦虑（躯体）评分。rs1927911-G患者还表现出较高的焦虑（身体症状）和焦虑（躯体）评分。rs11536889-GG患者的自杀评分显着降低，精神运动发育迟缓评分更高。rs11536889-G患者的自杀评分也显着降低，精神运动发育迟缓评分更高。rs7873784-G患者的焦虑（身体症状）和焦虑（心理）得分较高。抗抑郁药疗效与TLR4基因多态性之间无显着差异。这些发现提供了TLR4在焦虑，自杀，MDD患者的其他症状。在本研究中，未发现TLR4基因多态性与抗抑郁药疗效之间的关系。MDD患者的基因多态性和TLR4的表达尚需进一步研究。