Wound dressings have undergone continuous and substantial evolution over time. Modern bandage materials constitute of electrospun biopolymers that enable rapid and effective wound healing due to the high surface area to volume ratio of the electrospun nanofibers and their porous structure. In the present study, nanofibrous bandages, containing a blend of starch-thermoplastic polyurethane (TPU), were developed by using the electrospinning technique. The electrospun nanofibrous mats were subsequently crosslinked with varying concentrations of glutaraldehyde in order to increase their water stability and mechanical properties. The nanofibrous bandages were characterized for their structural properties using SEM, FTIR, TGA, DSC, as well as for their water retention ability, water vapor transmission rate (WVTR), tensile strength and blood clotting efficiency. Cytotoxicity of the bandages was evaluated using human dermal fibroblast cells. Furthermore, the extent of wound healing enabled by the nanofibrous bandage was ascertained using Sprague-Dawley rats. The results revealed that the starch-TPU nanofibrous bandages facilitated enhanced wound-healing, as compared to the traditional dressing material, such as the cotton gauze.

随着时间的推移，伤口敷料经历了连续而实质性的发展。现代绷带材料由电纺生物聚合物组成，由于电纺纳米纤维及其多孔结构的高表面积与体积之比，因此能够快速有效地修复伤口。在本研究中，使用静电纺丝技术开发了包含淀粉-热塑性聚氨酯（TPU）混合物的纳米纤维绷带。随后将电纺纳米纤维垫与不同浓度的戊二醛交联，以增加其水稳定性和机械性能。使用SEM，FTIR，TGA，DSC表征了纳米纤维绷带的结构特性，以及其保水能力，水蒸气透过率（WVTR），抗张强度和血液凝固效率。使用人皮肤成纤维细胞评估绷带的细胞毒性。此外，使用Sprague-Dawley大鼠确定了纳米纤维绷带使伤口愈合的程度。结果表明，与传统的敷料如棉纱布相比，淀粉-TPU纳米纤维绷带促进了伤口愈合。