Factors impacting lipid digestion and β-carotene bioaccessibility assessed by standardized gastrointestinal model (INFOGEST): oil droplet concentration.,Food & Function

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Factors impacting lipid digestion and β-carotene bioaccessibility assessed by standardized gastrointestinal model (INFOGEST): oil droplet concentration.
Food & Function ( IF 5.1 ) Pub Date : 2020-08-04 , DOI: 10.1039/d0fo01506g
Yunbing Tan ₁ , Zhiyun Zhang , Hualu Zhou , Hang Xiao , David Julian McClements

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Food, nutrition, and pharmaceutical scientists are trying to elucidate the major factors impacting the bioavailability of macronutrients (e.g., lipids) and micronutrients (e.g., vitamins) so as to improve their efficacy. Currently, there is still a limited understanding of how food matrix effects impact digestion and bioaccessibility determined under the INFOGEST model, which is currently the most widely used standardized in vitro gastrointestinal model. Therefore, we examined the impact of corn oil concentration on lipid digestion and β-carotene bioaccessibility using model food emulsions. For all oil concentrations tested (2.5 to 20%), complete lipid digestion was achieved using fed-state gastrointestinal conditions, which could only be seen if a back-titration was performed. The particle size and negative surface potential on the mixed micelles formed at the end of the small intestine phase both increased with increasing oil concentration, which was attributed to the generation of more free fatty acids. The β-carotene bioaccessibility increased when the oil concentration was raised from 2.5 to 10% due to the increased solubilization capacity of the mixed micelles, but then it decreased when the oil concentration was raised further to 20% due to precipitation and sedimentation of some of the β-carotene. The maximum β-carotene bioaccessibility (93.2%) was measured at 10% oil. These results indicate that the oil concentration of emulsions influences β-carotene bioaccessibility by altering digestion, solubilization, and precipitation processes. This knowledge is important when designing more effective functional or medical food products.

中文翻译：

通过标准化胃肠道模型（INFOGEST）评估的影响脂质消化和β-胡萝卜素生物可及性的因素：油滴浓度。

食品，营养和药物科学家正试图阐明影响大量营养素（例如脂质）和微量营养素（例如维生素）的生物利用度的主要因素，以提高其功效。目前，关于食物基质效应如何影响在INFOGEST模型下确定的消化和生物可及性的了解仍然有限，INFOGEST模型是目前使用最广泛的标准化体外方法。胃肠道模型。因此，我们使用模型食品乳剂检验了玉米油浓度对脂质消化和β-胡萝卜素生物可及性的影响。对于所有测试的油浓度（2.5％至20％），使用摄食状态的胃肠道条件都可以实现完全的脂质消化，只有在进行反向滴定的情况下才能看到。在小肠阶段结束时形成的混合胶束的粒径和负表面电位均随油浓度的增加而增加，这归因于更多游离脂肪酸的产生。当油的浓度从2.5％提高到10％时，由于混合胶束的增溶能力增强，β-胡萝卜素的生物利用度增加，但随后由于某些β-胡萝卜素的沉淀和沉淀而使油浓度进一步提高到20％时，油压下降。在10％的油中测得最大的β-胡萝卜素生物利用度（93.2％）。这些结果表明乳液的油浓度通过改变消化，增溶和沉淀过程来影响β-胡萝卜素的生物利用度。在设计更有效的功能性或医疗食品时，此知识很重要。

更新日期：2020-08-19

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