Ruthenium Metathesis: A Key Step To Access a New Cyclic Tetrasubstituted Olefin Platform.,Organic Letters

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Ruthenium Metathesis: A Key Step To Access a New Cyclic Tetrasubstituted Olefin Platform.
Organic Letters ( IF 4.9 ) Pub Date : 2020-08-03 , DOI: 10.1021/acs.orglett.0c01344
Clément F Heinrich ₁ , Didier Durand ₂ , Jérôme Starck ₂ , Véronique Michelet _{1,

3}

Affiliation

An rapid and mild synthetic route for the preparation of cyclic tetrasubstituted platforms via ruthenium-catalyzed ring-closing metathesis (RCM) has been developed. This process tolerates a wide range of functionalities such as nitrogen, oxygen, sulfur, silicon, and carbon tethered groups, as well as very challenging fluorine and boron atoms (36 derivatives, up to 96%). This diversity-oriented method was further demonstrated by the postfunctionalization reactions, such as Pd-couplings, N-substitution, and reductive amination introducing a morpholine moiety.

中文翻译：

钌复分解：访问新的环状四取代烯烃平台的关键步骤。

已经开发了一种快速，温和的合成途径，用于通过钌催化的闭环复分解（RCM）制备环状四取代的平台。该工艺可耐受各种功能，例如氮，氧，硫，硅和碳束缚基团，以及非常具有挑战性的氟和硼原子（36种衍生物，最高可达96％）。通过后功能化反应，例如Pd-偶联，N-取代和引入吗啉部分的还原胺化，进一步证明了这种面向多样性的方法。

更新日期：2020-09-20

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