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Diverse Types of Diterpenoids with an Aromatized C Ring from the Twigs of Podocarpus imbricatus.
Journal of Natural Products ( IF 5.1 ) Pub Date : 2020-08-03 , DOI: 10.1021/acs.jnatprod.0c00291
Bin Zhou 1, 2 , Yu-Hao Ren 1, 2 , Ying-Shan Han 3 , Thibault Mesplède 3 , Jian-Min Yue 1, 2
Affiliation  

An ethanol extract of the powdered twigs of Podocarpus imbricatus afforded 14 new diterpenoids (114), which all share an aromatized C ring. These isolates belong to five diterpenoid types that include abietanes (13), semperviranes (49), totaranes (1012), a C-17 norabietane (13), and an icetexane (14). Their structures were assigned mainly by analysis of the spectroscopic data, and the absolute configuration of 1 was determined by X-ray crystallography. A biosynthetic pathway for five of the biogenetically related types of diterpenoids was proposed. Compound 7 showed moderate inhibitory activity against Zika virus with an IC50 value of 2.5 μM.

中文翻译:

来自罗汉松枝条的具有芳香化 C 环的多种二萜类化合物。

的粉末状的细枝的乙醇提取物罗汉松鸡毛得到14个新的二萜类化合物(1 - 14),其中所有的份额的芳香C环。这些分离属于五个二萜类类型,包括abietanes(13),semperviranes(4 - 9),totaranes(10 - 12),一个C-17 norabietane(13),以及icetexane(14)。它们的结构主要通过光谱数据的分析来确定,1由 X 射线晶体学确定。提出了五种生物遗传学相关的二萜类化合物的生物合成途径。化合物7对寨卡病毒表现出中等抑制活性,IC 50值为 2.5 μM。
更新日期:2020-08-28
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