An urgent global quest for effective therapies to prevent and treat COVID-19 disease is ongoing. We previously described REGN-COV2, a cocktail of two potent neutralizing antibodies (REGN10987+REGN10933) targeting non-overlapping epitopes on the SARS-CoV-2 spike protein. In this report, we evaluate the in vivo efficacy of this antibody cocktail in both rhesus macaques and golden hamsters and demonstrate that REGN-COV-2 can greatly reduce virus load in lower and upper airway and decrease virus induced pathological sequalae when administered prophylactically or therapeutically. Our results provide evidence of the therapeutic potential of this antibody cocktail.

中文翻译：

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REGN-COV2抗体混合物可预防和治疗猕猴和仓鼠的SARS-CoV-2感染

全球正在迫切寻求有效的疗法来预防和治疗COVID-19疾病。我们先前描述了REGN-COV2，这是两种有效的中和抗体（REGN10987 + REGN10933）的混合物，其靶向SARS-CoV-2穗蛋白上的不重叠表位。在本报告中，我们评估了该抗体混合物在恒河猴和金仓鼠中的体内功效，并证明当预防性或治疗性给药时，REGN-COV-2可以大大降低上下呼吸道的病毒载量，并减少病毒引起的病理性红斑。我们的结果提供了该抗体混合物的治疗潜力的证据。