The current increase in the use of multi-herbal remedies coupled with loose regulation on public access to these products underscore research efforts to evaluate their biochemical effect, noting that many of the herbal medicines lack scientific evidence to support their medicinal claims. Objective: We therefore investigated the potential genotoxicity and hematotoxicity of commonly consumed multi-herbal formulations (YoyoBitters, Ogidiga and BabyOku) in Lagos, Nigeria, in experimental mice. Methods: Fifty (50) adult female albino mice were randomly selected and distributed into 5 groups of 10 mice each. Two mL/kg body weight of distilled water were orally administered to the control groups while BabyOku, YoyoBitters and Ogidiga herbal formulations were administered to the experimental groups at doses of 2 mL/kg body weights. Results: A dose- and tissue-dependent increase in induction of apoptotic DNA fragmentation was observed in the triherbal groups relative to control groups. Also, an increase in micronucleated polychromatic erythrocytes was formed in a dose-dependent manner in the multi-herbal groups when compared with the control groups. Conclusion: From our findings, multi-herbal formulations may possess hematotoxic and genotoxic potentials in mice.

中文翻译：

---

白化小鼠（小家鼠）中多种草药配方的潜在血液毒性和遗传毒性

当前多草药疗法的使用增加，加上公众对这些产品的宽松管制，突显了评估其生化作用的研究努力，并指出许多草药缺乏支持其医学主张的科学证据。目的：因此，我们调查了在尼日利亚拉各斯的实验小鼠中常用的多草药配方（YoyoBitters，Ogidiga和BabyOku）的潜在遗传毒性和血液毒性。方法：随机选择五十（50）只成年雌性白化病小鼠，分为5组，每组10只。对照组口服2mL / kg体重的蒸馏水，实验组以2mL / kg体重的剂量口服BabyOku，YoyoBitters和Ogidiga草药制剂。结果：相对于对照组，在三草药组中观察到凋亡DNA片段诱导的剂量和组织依赖性增加。而且，与对照组相比，在多草药组中以剂量依赖的方式形成了微核多色红细胞的增加。结论：根据我们的发现，多草药配方可能在小鼠中具有血液毒性和遗传毒性潜力。