Abstract

A theranostic amphiphilic nanocarrier based on iron oxide core with polyethyleneimine and poly(maleic anhydride-alt-1-octadecene) shell was synthesized, labeled with folic acid and loaded with Curcumin. Fe₃O₄@PIMF nanoparticles displayed a size of 20–30 nm with a shell thickness of 2–5 nm. Fe₃O₄@PIMF-CUR MNPs exhibited pH-responsive release behavior matched with Michaelis–Menten model. The MNPs showed more toxicity than free CUR against MCF-7 and Hela cells, while the drug-free carrier was safe against both cell lines. Hemolytic activity less than 1.5% in concentrations of <500 µg/mL indicated excellent blood compatibility. Appropriate negative signal enhancement in MRI confirmed the efficiency of the system for cancer theranostics.

摘要

合成了一种基于氧化铁核、聚乙烯亚胺和聚（马来酸酐-alt-1-十八烯）壳的治疗诊断两亲纳米载体，用叶酸标记并负载姜黄素。Fe ₃ O ₄ @PMIF 纳米颗粒的尺寸为 20-30 nm，壳厚度为 2-5 nm。Fe ₃ O ₄ @PMIF-CUR MNP 表现出与 Michaelis-Menten 模型相匹配的 pH 响应释放行为。MNPs 对 MCF-7 和 Hela 细胞表现出比游离 CUR 更大的毒性，而无药物载体对两种细胞系都是安全的。在 <500 µg/mL 的浓度下，溶血活性低于 1.5%，表明血液相容性极佳。MRI 中适当的负信号增强证实了该系统用于癌症治疗的效率。