ABSTRACT

In recent years, the usage of hydrogels in tissue regeneration and controlled drug release systems have been increasing rapidly due to their water holding capacity and 3D structure. In this study chitosan and dextran sulphate sodium were prefered to form pH-sensitive hydrogel by physical interaction. The biodegradability of the chitosan and the therapeutic properties of dextran sulphate sodium make them suitable as wound dressing material. In addition to these good specifications of polymers, vitamin-C and quercetin, which have an accelerating effect on wound healing. The structural and morphological characterisation of hydrogels were performed by FT-IR and SEM. The sweeling behaviour of this hydrogel was examined in PBS at different temperatures (25°C and 37°C) and pHs (6,7,7.4,8). In vitro release pattern of quercetin and vitamin-C were investigated. It was seen from this experiment that at the end of the 7 days, cell viability on loaded and unloaded hydrogel were higher than control group.

摘要

近年来，由于其保水能力和 3D 结构，水凝胶在组织再生和药物控释系统中的使用迅速增加。在这项研究中，壳聚糖和硫酸葡聚糖钠优选通过物理相互作用形成 pH 敏感水凝胶。壳聚糖的生物降解性和硫酸葡聚糖钠的治疗特性使其适合作为伤口敷料材料。除了聚合物、维生素 C 和槲皮素的这些良好规格外，它们对伤口愈合具有加速作用。水凝胶的结构和形态表征通过 FT-IR 和 SEM 进行。在不同温度（25°C 和 37°C）和 pH（6、7、7.4、8）下，在 PBS 中检查了这种水凝胶的溶胀行为。研究了槲皮素和维生素 C 的体外释放模式。从这个实验可以看出，在第7天结束时，加载和卸载的水凝胶上的细胞活力均高于对照组。