Abstract This paper aims to correlate Alzheimer's disease (AD) related striatal pathologic changes with the fractional amplitude of low-frequency fluctuations (fALLF) in the blood oxygenation level-dependent (BOLD) signal in the resting state functional Magnetic Resonance Imaging (rs-fMRI). A dopamine modulated Izikhevich neuron model based network of striatum region is constructed. Balloon–Windkessel hemodynamic model is used to obtain BOLD signals. fALFF differences between two frequency bands (slow-5:0.01–0.027 Hz; slow-4:0.027–0.073 Hz) are investigated in the case of dopamine depletion, decrease in the synaptic connectivity and the input from cortical and thalamic region, assumed that they are the degenerations occurring in AD.

中文翻译：

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阿尔茨海默病相关纹状体病理变化对低频波动幅度分数的影响

摘要 本文旨在将阿尔茨海默病 (AD) 相关纹状体病理变化与静息状态功能性磁共振成像 (rs-fMRI) 中血氧水平依赖性 (BOLD) 信号的低频波动幅度 (fALLF) 相关联。 ）。构建了基于多巴胺调制的 Izikhevich 神经元模型的纹状体区域网络。Balloon-Windkessel 血流动力学模型用于获得 BOLD 信号。在多巴胺耗竭、突触连接性降低以及来自皮质和丘脑区域的输入的情况下，研究了两个频带（慢速 5:0.01–0.027 Hz；慢速 4:0.027–0.073 Hz）之间的 fALFF 差异，假设它们是发生在 AD 中的退化。